Scientific Publications from Queen’s University Research Group:

Heaton, J. P., M. A. Adams, C. H. Graham, L. Emerson, R. D. Siemens. Evidence for the use of low dose nitric oxide in the treatment of rising PSA associated with biochemical failure following radical prostatectomy. Abstract: The Journal of Urology 169 (4): 1082 Suppl. S Apr 2003.

L. Freideriksen, R. Sullivan, L. Maxwell, S. Macdonald-Goodfellow, M. Adams, B. Bennet, D. R. Siemens, C.H. Graham. Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling. In Press, Clinical Cancer Research 13, 2007.

Matthews, N.E., Adams, M.A., Maxwell, L.R., Gofton, T.E., and Graham, C.H. (2001) Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J. Natl. Cancer Inst. 93: 879-885.

Postovit, L-M., Adams, M.A., Lash, G.E. Heaton, and Graham, C.H. (2002) Oxygen-mediated regulation of tumour cell invasiveness: Involvement of a cyclic GMP-dependent pathway. J. Biol. Chem. 277(35): 35730-35737.

Postovit, L-M., Adams, M.A., Lash, G.E., Frederiksen, L.J., Heaton, J.P.W., and Graham, C.H. (2004). Nitric oxide-mediated regulation of hypoxia-induced B16F10 melanoma metastasis. Int. J. Cancer 108: 47-53.

C.H. Graham , T. E. Fitzpatrick, and K. R. McCrae. Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway. Blood, Vol 91, No 9 (May 1), 1998: pp 3300-3307

G. E. Lash, L-M. Postovit, N. E. Matthews, E. Y. Chung, M. T. Canning, H. Pross, M. A. Adams, and C. H. Graham. Oxygen as a regulator of cellular phenotypes in pregnancy and cancer. Can. J. Physiol. Pharmacol. 80: 103-109 (2002)

C. H. Graham, J. Forsdike, C. J. Fitzgerald and S. MacDonald-Goodfellow. Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int. J. Cancer: 80, 617-623 (1999)

L-M. Postovit, M. A. Adams, G. E. Lash, J. P.W. Heaton, and C. H. Graham. Nitric oxide-mediated regulation of hypoxia-induced B16F10 melanoma metastasis. Int. J. Cancer: 108, 47-53 (2004)

L. J. Frederiksen, D. R. Siemens, J. P. Heaton, L. R. Maxwell, M. A. Adams and C. H. Graham. Hypoxia induced resistance to doxorubicin in prostate cancer is inhibited by low concentrations of glyceryl trinitrate. Journal of Urology, Vol. 170, 1003-1007, September 2003

C.P. Muir, M.A. Adams, and C.H. Graham. Nitric oxide attenuates resistance to doxorubicin in three-dimensional aggregates of human breast carcinoma cells. Breast Cancer Research and Treatment (2005), DOI 10.1007/s10549-005-9076-9.

L-M. Postovit, R. Sullivan, M. A. Adams, C. H. Graham. Nitric oxide signalling and cellular adaptations to changes in oxygenation. Toxicology 208 (2005) 235-248.

D. R. Siemens, N. Hu, A. K. Sheikhi, E. Chung, L. Frederiksen, H. Pross, and C. H. Graham. Hypoxia Increases Tumor Cell Shedding of MHC Class I Chain-Related Molecule: Role of Nitric Oxide. Cancer Res 2008; 68: (12). June 15, 2008

D. Robert Siemens, Jeremy P. W. Heaton, Michael A. Adams, Jun Kawakami and Charles H. Graham. Phase ll Study of Nitric Oxide Donor for Men With Increasing Prostate-specific Antigen Level After Surgery or Radiotherapy for Prostate Cancer. Urology 74: 878-883, 2009