Nitric Oxide and The Treatment of Hypoxia

Evidence generated in laboratories at Queen’s University has demonstrated the capacity of low-dose nitric oxide donors (such as NOVade™) to reverse the effects of hypoxia. NOVade™ effects a phenotype change in cancer cells, but does not spuriously suppress PSA. NOVade™ has been shown to work in numerous types of cancer and alone or in combination with other agents.

References:

L. Freideriksen, R. Sullivan, L. Maxwell, S. Macdonald-Goodfellow, M. Adams, B. Bennet, D. R. Siemens, C.H. Graham. Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling. In Press, Clinical Cancer Research 13, 2007.